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| Effects of Labrasol on the corneal permeability for Breviscapinun |
| Hits 1613 Download times 2131 Received:November 30, 2010 |
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| DOI
10.11656/j.issn.1673-9043.2011.01.19 |
| Key Words
Labrasol;corneal permeability;breviscapinun |
| Author Name | Affiliation | | LI Nan | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China | | LI Lin | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China | | WU Haohui | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China | | 赵海南 | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China | | 刘志东 | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 300193, China |
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| Abstract
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| [Objective] To investigate the effect of Labrasol on the corneal permeability for Breviscapinun and explore its use in ophthalamologic preparation.[Methods] The effects of Labrasol on the corneal permeability for breviscapinun were investigated in vitro,using isolated rabbit corneas.[Results] In the presence of Labrasol at a concentration between 0.5% and 5.0%,the maximum apparent permeability coefficient (Papp) was 2.41-,4.11-,4.18-, 4.14-,and it was 2.86-folds for breviscapinun,respectively,compared with contro (P<0.01),However,5.0% Labrasol could not improve the appeared permeability for breviscapinun (P>0.01).[Conclusion] labrasol at 0.5% ~2.0% has potential clinical benefits in improving the ocular drug delivery of breviscapinun and has not irritation to eye tissues. |
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