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| Changes of serum free calcium and cellular rheology in rat with blood stasis syndrome induced by cold |
| Hits 1688 Download times 1528 Received:February 01, 2011 |
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| DOI
10.11656/j.issn.1673-9043.2011.02.13 |
| Key Words
blood stasis syndrome induced by cold;rat;serum free calcium;cellular rheology |
| Author Name | Affiliation | | LU Yi-zhu | Tianjin University of TCM, Tianjin 300193, China | | CHEN Xiao-xu | The First Hospital Affiliated to Tianjin University of TCM, Tianin 300193, China | | CAI Qi-ling | Tianjin Nankai Hospital, Tianjin 300100, China | | 王学岭 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To explain the biological basis of the syndrome deeply by investigating the changes of cellular rheology and serum free calcium in rat with external manifestations of blood stasis syndrome induced by cold. [Methods] The rat model of blood stasis syndrome induced by cold was set up by using the methods of injecting adrenalin and being immersed in ice water. After finishing the experiment, the index of serum free calcium, erythrocyte aggregation, erythrocyte distortion, erythrocyte rigidity, hematocrit and blood sedimentation were determined. [Results] In the model group, serum free calcium, blood sedimentation, erythrocyte aggregation, erythrocyte rigidity and hematocrit obviously increased and erythrocyte distortion decreased, which were different from normal control group (P<0.05 or P<0.01). [Conclusion] The external manifestations of blood stasis syndrome induced by cold can be obtained by using the methods of injecting adrenalin and being immersed in ice water. The corresponding changes of cellular rheological index can reflect the biological basis of the blood stasis syndrome exactly. |
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