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| Gulening capsules on rat model of fracture callus VEGF effects |
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| DOI
10.11656/j.issn.1673-9043.2011.03.14 |
| Key Words
traditional Chinese medicine;fracture healing;VEGF |
| Author Name | Affiliation | | REN Shou-ping | Beichen Affiliated Hospital of Tianjin University of TCM, Tianjin 300400
| | ZHANG Rong-wei | Beichen Affiliated Hospital of Tianjin University of TCM, Tianjin 300400
| | JIN Hong-bin | Trauma Center, Tianjin Hospital, Tianjin 300211 |
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| Abstract
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| [Objective] To discuss the therapeutic effect of traditional Chinese medicine of tonifying qi invigorate the circulation of blood to promoting fracture cooperation.[Methods] There were 66 rats with right shin bone injured,which were divided into Gulening high dose group,low dose group,activating blood and dissolving stasis group and control group.Each group was divided into 4 slaps to execute in 7,14,21,28d,selecting fracture model part callus to immunohistochemisty coloration,recording the quantity and area of VEGF positive express celled in bone scab.[Results] During 7d and 21d,VEGF positive express celled quantity of Gulening high dose group and area was higher than that of activating blood and dissolving stasis group (P<0.05).[Conclusion] Gulening capsule is contribute to the combining and releasing of VEGF in fracture healing early stage,and its effect is better obviously than pure traditional Chinese medicine of activating blood and dissolving stasis. |
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