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| Pharmacokinetics of stilbene glycoside and its β-cyclodextrin inclusion in rats |
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| DOI
10.11656/j.issn.1673-9043.2011.03.15 |
| Key Words
stilbene glycoside (THSG);β-cyclodextrin;HPLC;pharmacokinetics |
| Author Name | Affiliation | | OU-YANG Hui-zi | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | REN Xiao-liang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | WANG Qiang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 王贵芳 | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 赵敏 | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 戚爱棣 | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] The pharmacokinetics characteristics of stilbene glycoside (THSG) and itsβ-cyclodextrin inclusion after oral administration in rats were studied.[Methods] After the administration,blood samples were collected at regular times from orbital venous plexus.The plasma concentration of THSG was determined quantitatively by HPLC-UV.[Results] The HPLC-UV method was available for analysing THSG in plasma and met the requirements of biological sample analysis.The pharmacokinetic parameters were calculated by using DAS(Drug and Statistics)VER 1.0 software.The fast absorption of THSG contributed to a higher Cmax of complex and that of free THSG[(1.16±0.80)mg/L vs.(0.24±0.09)mg/L for complex and free THSG,respectively,P<0.05].It was also found that AUC was dramatically higher for complex than that of free THSG [(32.24±7.77)mg(L·min) vs.(11.50±3.97)mg/(L·min) for complex and free THSG,respectively,P<0.05].[Conclusion] Pharmacokinetic studies of THSG/β-cyclodextrin complex in rats have indicated that the complex has higher bioavailability compared to free THSG,suggesting that the complex may exhibit better therapeutic efficacy. |
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