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| Study of ion-activated in situ gel system containing berberine hydrochloride for ocular use |
| Hits 1861 Download times 2042 Received:April 11, 2011 |
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| DOI
10.11656/j.issn.1673-9043.2011.04.12 |
| Key Words
berberine hydrochloride;ion-activated in situ gel;gellan gum |
| Author Name | Affiliation | | LI Lin | Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese medicine, Ministry of Education, Tianjin 300193, China
Tianjin University of TCM. Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China | | ZHAO Hai-nan | Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese medicine, Ministry of Education, Tianjin 300193, China
Tianjin University of TCM. Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China | | LI Jia-wei | Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese medicine, Ministry of Education, Tianjin 300193, China
Tianjin University of TCM. Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China | | 李楠 | Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese medicine, Ministry of Education, Tianjin 300193, China
Tianjin University of TCM. Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China | | 王颖 | Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese medicine, Ministry of Education, Tianjin 300193, China
Tianjin University of TCM. Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China | | 刘志东 | Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese medicine, Ministry of Education, Tianjin 300193, China
Tianjin University of TCM. Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China |
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| Abstract
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| [Objective] To prepare and evaluate the ion-activated in situ gel system containing berberine hydrochloride for ocular use.[Methods] The ion-activated in situ gel of berberine hydrochloride was prepared by using gellan gum as ion-activating material.Rheological quality was investigated by examination of the viscosity. Ocular residence time was determined by fluorescence-labeled technique.[Results] The investigation of the rheological curve demonstrated that the ion-activated in situ gel of berberine hydrochloride represented a pseudoplastic flow type.Both ion-activated in situ gel of berberine hydrochloride and the eye-drop of Berberine had no irritation after ocular administration.Ocular residence time of ion-activated in situ gel of berberine hydrochloride was 6 times higher than that of eye-drop of Berberine.[Conclusion] As liquid ophthalmic delivery systems,ion-activated in situ gel of berberine hydrochloride can undergo in situ phase transition to form gels,which can prolong the residence time of in-situ gelling agent to enhance the effect of drug at the target site without irritation to the eye. |
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