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| Expression of ILK, TNFα in rats with alcoholic hepatic fibrosis and intervention effect of Wutianbaoganye |
| Hits 2568 Download times 2359 Received:November 06, 2011 |
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| DOI
10.11656/j.issn.1673-9043.2012.01.08 |
| Key Words
Wutianbaoganye;alcohol hepatic fibrosis;ILK;TNFα |
| Author Name | Affiliation | | SU Jin-ling | Tianjin University of TCM, Tianjin 300193, China | | BI Ye-Dong | Tianjin Hangu Hospital of TCM, Tianjin 300480, China | | JIANG Xi-Juan | Tianjin University of TCM, Tianjin 300193, China | | SONG Xing-xing | Tianjin University of TCM, Tianjin 300193, China | | FAN Ying-Chang | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To investigate the expression of ILK,TNFαmRNA in rats with alcoholic hepatic fibrosis and the intervention effect of Wutianbaoganye.[Methods] 100 Wistar rats were assigned at random into six groups:normal group (10),model control group (18),Wutianbaoganye low dose group (18),middle dose group (18),high dose group (18),Yishanfu group (18).Alcohol hepatic fibrosis was induced in rats by intragastric administration of the mixture of liquor,pyrazol and corn oil.After intervention for 12 weeks,the degree of hepatic fiborsis was observed by HE,and the expression of ILK,TNFαmRNA in liver tissue were detected by RT-PCR.[Results] Compared with rats in model control group,Wutianbaoganye (especially the middle and the high dose) and Yishanfu group could suppress the development of fibrosis and could decrease the expression of ILK,TNFαmRNA.[Conclusion] Wutianbaoganye has an active effect on ameliorating alcohol hepatic fibrosis in rats.The mechanism may be decreasing the expression of ILK,TNFαmRNA to inhibit the occurrence and development of alcohol hepatic fibrosis. |
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