|
| The effect of rat platelet aggregation and platelet cyclic AMP metabolism by Ginsenoside Rg1 |
| Hits 2860 Download times 3089 Received:October 26, 2011 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2012.01.11 |
| Key Words
Rg1;platelet;aggragation;cAMP |
| Author Name | Affiliation | | HUA Shen-yu | Tianjin State Key Laboratory Medicine, Tianjin University of TCM, Tianjin 300193, Chinese | | QU Feng | Tianjin State Key Laboratory Medicine, Tianjin University of TCM, Tianjin 300193, Chinese | | CHEN Li-ping | Tianjin State Key Laboratory Medicine, Tianjin University of TCM, Tianjin 300193, Chinese | | KANG Li-yuan | Tianjin State Key Laboratory Medicine, Tianjin University of TCM, Tianjin 300193, Chinese | | ZHANG Bo-li | Tianjin State Key Laboratory Medicine, Tianjin University of TCM, Tianjin 300193, Chinese | | 张伯礼 | Tianjin State Key Laboratory Medicine, Tianjin University of TCM, Tianjin 300193, Chinese |
|
| Abstract
|
| [Objective] To explore the effective components of ginsenoside Rg1 on rat platelet aggregation and cAMP.[Method] Using turbidimetry in different concentration of Rg1 (0.5、1.5、2.5、3、4 mmol/L) of rats in vitro induced inhibition of platelet aggregation,to positive drug aspirin was used as control;to study the content of cAMP on rat platelet by Rg1.[Results] 0.5 mmol/L ginseng saponins group Rg1 on platelet aggregation effect;aspirin group and ginsenoside Rg1 (4、3、2.5、1.5 mmol/L) group maximal aggregation ratio were significantly smaller than the negative control group (P<0.01),the inhibition rates were 18.95%、59.04%、40.37%、29.77%、9.77%;Rg1 of different concentration groups on ADP after induction of platelet cAMP content and ADP group were not significant difference.[Conclusion] Rg1 can inhibit platelet activation,but not by elevating the content of rat platelet. |
|
|
|
|
|
