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| Effects of 1.8-Dihydroxy-3-carboxy-anthraquinone on LPS-induced microglial activation |
| Hits 2675 Download times 2368 Received:September 16, 2011 |
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| DOI
10.11656/j.issn.1673-9043.2012.01.12 |
| Key Words
1.8-Dihydroxy-3-carboxy-anthraquinone;microglia;inflammation |
| Author Name | Affiliation | | JING Hao-ran | Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China | | CHAI Li-juan | Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China | | GUO Hong | Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China | | LI Mei-jiao | Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China | | LIU Qing-qing | Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China | | WANG Shao-xia | Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] This study examined whether 1.8-Dihydroxy-3-carboxy-anthraquinone,a metabolite from Salvia miltiorrhiza,may exert an anti-inflammatory effect in microglia.[Methods] We examined the effect of 1.8-Dihydroxy-3-carboxy-anthraquinone on cell viability and the production of nitric oxide (NO) induced by LPS treatment in rat primary cultured microglia.[Results] 1.8-Dihydroxy-3-carboxy-anthraquinone could significantly inhibit the production of NO by LPS treatment in rat primary cultured microglia.[Conclusion] 1.8-Dihydroxy-3-carboxy-anthraquinone can suppress microglial activation and this may be a mechanism underlying the neuroprotective activity of it. |
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