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| Clinic and mechanism study of Tongbu Xinbao capsule on congestive heart failure |
| Hits 1797 Download times 1841 Received:February 17, 2012 |
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| DOI
10.11656/j.issn.1673-9043.2012.02.07 |
| Key Words
Tongbu Xinbao capsule;CHF;clinic and mechanism;study |
| Author Name | Affiliation | | HUANG Chuan-hui | Tianjin University of TCM, Tianjin 300193, China | | FAN Rui-hong | Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China |
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| Abstract
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| [Objective] To compare the effect of Tongbu Xinbao capsules (TBXBCs) and Buyi Qiangxin tablets (BYQXTs) on chronic congestive heart failure (CHF) and observe the level of plasma endothelin (ET), nitric oxide (NO) and brain natriuretic peptide (BNP) in CHF patients.[Methods] The 120 CHF patients with heart and kidney Yang deficiency and internal water and dampness retention were selected and using a randomized single blind method they were divided into treatment group and control group. The patients in both groups were given routine Western medicine, but TBXBCs were added in treatment group and BYQXTs in control group. Two months was one course. TCM syndrome before and after treatment, quality of life, heart function, heart color Doppler ultrasonic echocardiography, plasma ET, NO, BNP of two groups were observed.[Results] Compared with control group, the heart failure symptoms, quality of life and heart function were significantly improved in treatment group (P<0.05). The ejection fraction (EF) and the left ventricular end-systolic dimension (LVESD) were improved significantly (P<0.05); NO, ET and BNP were significantly decreased in treatment group (P<0.05).[Conclusion] TBXBCs can improve symptoms and quality of life in CHF patients and can significantly inhibit the increasing of plasma ET, NO levels, decrease the level of BNP at the same time. It can also significantly improve and adjust the CHF hemodynamics. |
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