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| Effect of paeoniflorin on cerebral neurotrnsmitter in forced-swimming mice |
| Hits 2591 Download times 2424 Received:December 30, 2011 |
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| DOI
10.11656/j.issn.1673-9043.2012.02.08 |
| Key Words
paeoniflorin;antidepressant;monoamine transmitters |
| Author Name | Affiliation | | CUI Guang-zhi | Tianjin University of TCM, Tianjin 300193, China | | JIN Shu-mei | Tianjin Hospital of Huanhu, Tianjin 300060, China |
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| Abstract
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| [Objective] To investigate the antidepressant effects and the possible mechanism of paeoniflorin.[Methods] The antidepressant effects was evaluated by forced-swimming tests (FST). The content of monoamine neurotransmitters was measured by the HPLC assay.[Results] Paeoniflorin (100 and 200 mg/kg) could significantly reduce the duration of immobility in FST, and Paeoniflorin (200 mg/kg) can significantly increase the contents of Norepinephrine (NE), dopaimine (DA) and 5-hydroxytryptamine (5-HT) in mouse brain.[Conclusion] Paeoniflorin has remarkable antidepressant effect, and its mechanism may be involved in monoaminergic nervous system. |
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