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| Influence of external use of rhizoma drynariae on experimental vitiligo |
| Hits 1764 Download times 2418 Received:December 24, 2011 |
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| DOI
10.11656/j.issn.1673-9043.2012.02.11 |
| Key Words
rhizoma drynariae;vitiligo;guinea pig model |
| Author Name | Affiliation | | SHEN Li | The Research Institute of TCM, Tianjin University of TCM, Tianjin 300193, china | | ZHANG De-qin | The Research Institute of TCM, Tianjin University of TCM, Tianjin 300193, china | | HUANG Yun-ying | The Research Institute of TCM, Tianjin University of TCM, Tianjin 300193, china | | WANG Xue-ni | The Research Institute of TCM, Tianjin University of TCM, Tianjin 300193, china | | DU Juan | The Research Institute of TCM, Tianjin University of TCM, Tianjin 300193, china | | WANG Yuan-yuan | The Research Institute of TCM, Tianjin University of TCM, Tianjin 300193, china |
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| Abstract
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| [Objective] To study the therapeutic effect of external use of rhizoma drynariae on experimental vitiligo guinea pig model, and provide some pharmacodynamics references basis for its function of resolving wind and expelling macula in Chinese Pharmacopeia (ChP).[Methods] Vitiligo was produced by chemical decoloration method. The influence of the tested drug on the guinea pig skin melanin distribution and the blood tyrosinase (TYR), cholinesterase (CHE) and single amine (MAO) were measured.[Results] The external use of rhizoma drynariae showed good effects on the animal models. It could highly improve the skin melanin generation compared with that in model group, and can also increase the activity of TYR, CHE and MAO.[Conclusion] The external use of rhizoma drynariae shows good effects on the guinea pig model model. |
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