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| Optimization in preparation process of Qingkailing oral liquid |
| Hits 2700 Download times 2544 Received:February 28, 2012 |
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| DOI
10.11656/j.issn.1673-9043.2012.02.13 |
| Key Words
Qingkailing oral liquid;geniposide;HPLC;orthogonal test;extraction and purification |
| Author Name | Affiliation | | WANG Lei | TCM Chemistry and Analysis Key Laboratory of Tianjin, Tianjin 300193, China | | GAO Hui | Pharmaceutical Co. Ltd of Tangshan Rongda, Tangshan 063020, China | | CHAN Ai-fu | Pharmaceutical Co. Ltd of Tangshan Rongda, Tangshan 063020, China | | LIU Er-wei | TCM Chemistry and Analysis Key Laboratory of Tianjin, Tianjin 300193, China | | WANG Jia-long | TCM Chemistry and Analysis Key Laboratory of Tianjin, Tianjin 300193, China |
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| Abstract
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| [Objective] To optimize the condition for the extraction and alcohol-purification process of Qingkailing oral liquid.[Methods] Monitoring geniposide by HPLC detection means,the orthogonal design L9 (34) was used for the inspection of water-extracting process and alcohol-precipitating process.[Results] The condition for the extraction and purification process of Qingkailing oral liquid was as follows: soaking the medicinal materials with 9 folds of water for 1 hour, decocting 2 times for 2 hours. Both alcohol precipitated solutions were concentrated to the concentration of 1:1(material:solution volume), then added 95% alcohol,precipitated by 70% alcohol solution, moderated pH to 6; the extraction rate of geniposide was 64.8%.[Conclusion] The optimum process is repeatable, the extraction rate of geniposide is high, recovery rate of solids are suitable. This research result has attained the goal of optimizing production process. |
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