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| Investigation of processing technology of zedoary turmeric oil-cyclo dextrin inclusion compound |
| Hits 2226 Download times 2325 Received:March 05, 2012 |
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| DOI
10.11656/j.issn.1673-9043.2012.02.14 |
| Key Words
zedoary turmeric oil;cyclodextrin;inclusion compound;processing technology |
| Author Name | Affiliation | | WANG Yan | Tianjin University of TCM, Tianjin 300193 China | | ZHANG Tie-jun | Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract
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| [Objective] To compare the inclusion effect of different types of cyclodextrin (αcyclodextrin, βcyclodextrin, γcyclodextrin) on zedoary turmeric oil, study the best preparation technology of zedoary turmeric oil and cyclodextrin inclusion compound.[Methods] Using the saturated water solution method, α-cyclodextrin, βcyclodextrin, γ-cyclodextrin zedoary turmeric oil inclusion compound were prepared and using X ray diffraction method the inclusion effect was identified; using L9 (34) orthogonal experimental design, the best preparation technology of zedoary turmeric oil and cyclodextrin inclusion compound was optimized.[Results] Under the same conditions, αcyclodextrin and zedoary turmeric oil could not form inclusion compound, the inclusion rate of γ-cyclodextrin and βcyclodextrin inclusion rate were almost the same. Taking the inclusion rate and oil utilizing rate as the indexes, the optimum process of zedoary turmeric oil and β-cyclodextrin inclusion compound was 8:1 of A3B1C2:β-cyclodextrin: Oil (g/mL), the inclusion temperature was 40℃ and the inclusion time was 90 min. According to the best prescription process parameters 3 experiments were repeatedly performed. It was found that the volatile oil inclusion rate was 90.90% and the oil utilizing rate was 66.67%, RSD<2.7% . The results showed that physical mixture of X ray spectrum was different between inclusion complexes with cyclodextrins and volatile oil with cyclodextrin.[Conclusion] The technology is reasonable and the cost can be saved when selecting β-cyclodextrin inclusion zedoary turmeric oil. |
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