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| Preliminary study on permeability of Jinhuanggao by transcutaneous microdialysis in rats in vitro |
| Hits 1855 Download times 2117 Received:May 13, 2012 |
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| DOI
10.11656/j.issn.1673-9043.2012.03.07 |
| Key Words
cutaneous microdialysis;berberine hydrochloride;transdermal delivery;HPLC |
| Author Name | Affiliation | | ZHANG Qian | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China | | YIN Zhong-peng | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China | | ZHAO Hai-nan | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China | | PANG Xiao-chen | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China | | MA Li | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China | | GUO Lin | Second Affiliated Hospital of Tianjin University of TCM, Tianjin 300150, China | | LIU Zhi-dong | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China | | WANG Hong | Second Affiliated Hospital of Tianjin University of TCM, Tianjin 300150, China |
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| Abstract
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| [Objective] To study the transcutaneous absorption of Jinhuanggao in rats.[Methods] An in vivo sampling technique and transcutaneous microdialysis were used to determine the drug concentration in dermis in rats.The recovery of the microdialysis probe was adopted to assess in vivo according to the retrodialysis method.[Results] The recovery in vivo was(32.81±1.33)% by retrodialysis method.The steady state flux of berberine hydrochloride in dialysate was 2.73 ng/h,and the lag time was 1.5 h.[Conclusion] The active ingredient in Jinhuanggao has a good retention amount under the skin.So this preparation is suitable for transdermal drug delivery. |
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