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| Preparation of ophthalmic solid lipid nanoparticles loading berberine hydrochloride |
| Hits 2660 Download times 2556 Received:March 18, 2012 |
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| DOI
10.11656/j.issn.1673-9043.2012.03.09 |
| Key Words
berberine hydrochloride;solid lipid nanoparticle;cornea permeation in vitro |
| Author Name | Affiliation | | LI Jia-wei | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China | | ZHAO Hai-nan | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China | | GUO Xiu-jun | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China | | Aggrey MO | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China | | LIU Zhi-dong | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China | | LI Nan | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China | | LI Lin | Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China | | PAN Wei-san | Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract
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| [Objective] To prepare ophthalmic solid lipid nanoparticles loading berberine hydrochloride.[Methods] The solid lipid nanoparticles loading berberine hydrochloride were prepared by emulsification-ultrasonic method.The isolated cornea permeation test of the formulation was studied in rabbit.The permeated amount of berberine hydrochloride was determined by high performance liquid chromatography.[Results] The entrapment efficiencies of nanoparticle was 51.1%.The average partic1e size was(19±2)nm.The zeta potential was -11.5 mV.The transparent coefficient of the formulation was(1.46±0.45)×10-6 cm/s,increased for 16% when compared with control (P<0.05).[Conclusion] The preparation technique is simple and stable,which could be used to prepare the solid lipid nanoparticles loading berberine hydrochloride. |
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