|
| Effects of extract of pomegranate peel on proliferation and apoptosis of breast cancer cell line MDA-MB-231 |
| Hits 2470 Download times 2413 Received:October 12, 2012 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2012.04.08 |
| Key Words
extract of pomegranate peel;breast cancer;apoptosis;MDA-MB-231 cells |
| Author Name | Affiliation | | ZHANG Xun | Academy of TCM of Jiangsu Province, The Hospital of Integrated Chinese and Western Medicine, Nanjing 210028, China | | WU Ai-ping | The First Clinical Medical College of Nanjing University of TCM, Jiangsu Province Hospital of TCM, Nanjing 210029, China | | ZHANG Yong-hong | The First Clinical Medical College of Nanjing University of TCM, Jiangsu Province Hospital of TCM, Nanjing 210029, China |
|
| Abstract
|
| [Objective] To investigate the effects of extract of pomegranate peel on proliferation and apoptosis of breast cancer cell line MDA-MB-231. [Methods] MTT assay was used to measure the anti-proliferation effect of extract of pomegranate peel in breast cancer line MDA-MB-231. The apoptosis and the cell cycle were analyzed by flow cytometry. [Results] The extract could inhibit the proliferation of breast cancer cell line MDA-MB-231 in dose-and time-dependent manner. It could induce the apoptosis of MDA-MB-231 cells. The growth of cancer cells was arrested in G2-M phase. [Conclusion] Extract of pomegranate peel can inhibit the proliferation of breast cancer cell line MDA-MB-231, induce apoptosis and block the growth of cancer cells in G2-M phase. |
|
