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| Effects of ginkgo biloba extract on fetal rat cortical neuronal cells |
| Hits 2023 Download times 2347 Received:October 20, 2012 |
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| DOI
10.11656/j.issn.1673-9043.2012.04.09 |
| Key Words
ginkgo biloba extract;fetal rat cortical neuronal cells;cell activity;cell membrane;cellular oxidation resistance |
| Author Name | Affiliation | | Zhang Hao-nan | Tianjin University of TCM, Tianjin 300193, China | | Wang Yi-min | Tianjin University of TCM, Tianjin 300193, China | | Wang Yun-hua | Tianjin University of TCM, Tianjin 300193, China | | HE Pan | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To study the effects of ginkgo biloba extract on fetal rat cortical neuronal cells under normal and hypoxic cell cultivations. [Methods] Under normal and hypoxic cultivations, test the control and dosing groups separately, for the cell activity values, and Lactate Dehydrogenase (LDH), Superoxide Dismutase (SOD), and Malondialdegyde (MDA) values in the cellular supernatant. [Results] Under normal cell cultivation, the cell activity values of the dosing group were higher than those of the control group; the differences were statistically significant. The LDH values of the dosing group were lower than those of the control group; the differences were statistically significant. The SOD and MDA values of the dosing group were different from those of the control group; the differences were not statistically meaningful. Under hypoxic cell cultivation, the cell activity values of the dosing group were higher than those of the control group; the differences were statistically significant. The LDH values of the dosing group were higher than those of the control group; the differences were statistically significant. The SOD and MDA values of the dosing group were higher than those of the control group; the differences were statistically significant. [Conclusion] Under normal cell cultivation, the ginkgo biloba extract can stimulate the cortical neuronal cells' growth, reduce cell membrane damage, and has no notable effects on cellular oxidation resistance. Under hypoxic cell cultivation, the ginkgo biloba extract can stimulate the cortical neuronal cells' growth, increase cell membrane damage, and increase cellular oxidation resistance. |
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