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| Correlation between four indicators of collagen and pathological stage in patients of chronic hepatitis B with blood stasis-obstructing collaterals |
| Hits 2410 Download times 1629 Received:December 25, 2012 |
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| DOI
10.11656/j.issn.1673-9043.2013.01.04 |
| Key Words
chronic hepatitis B;syndrome of blood stasis obstructing the collaterals; four indicators of liver fibrosis;pathological staging |
| Author Name | Affiliation | E-mail | | TANG Ge | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | | GUO Hui | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | guohui0305@126.com |
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| Abstract
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| [Objective] To analyze the correlation between four indicators of liver fibrosis and the pathological stage in chronic hepatitis B patients with syndrome of blood stasis obstructing the collaterals. [Methods] We collected 60 patients diagnosed as chronic hepatitis B, and 30 patients had syndrome of blood stasis obstructing the collaterals and 30 patients had syndrome of hepatic stagnation and spleen deficiency. We checked their HA, LN, PCⅢ and Ⅳ-C by radioimmunoassay and observed the pathological changes simultaneously to evaluate their liver inflammation and fibrosis level. [Results] The levels of PCⅢ, HA, LN and Ⅳ-C in patients with syndrome of blood stasis obstructing the collaterals were significantly elevated and the liver pathological stage ranges mainly from G3～G4 to S3～S4. The levels of HA and Ⅳ-C in patients with syndrome of hepatic stagnation and spleen deficiency were elevated significantly and their liver pathological ranges mainly from G0～G2 to S0～S2. [Conclusion] The levels of HA and Ⅳ-C in patients with syndrome of blood stasis obstructing the collaterals were elevated. The degree of liver inflammation and fibrosis was severe with positive correlation. LN and PCⅢ, as the primary diagnostic indicators of liver fibrosis, are still not sensitive enough. |
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