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| Investigation on corneal permeability for Baicalin of SolutolHS 15 in vitro |
| Hits 2444 Download times 2048 Received:December 15, 2012 |
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| DOI
10.11656/j.issn.1673-9043.2013.01.10 |
| Key Words
SolutolHS 15;corneal permeability;Baicalin |
| Author Name | Affiliation | E-mail | | ZHANG Rui | Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China | | | ZHAO Hai-nan | Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China | | | QU Ji-lan | Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China | | | LI Lin | Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China | | | LI Nan | Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China | | | LIU Zhi-dong | Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China | lonerliuzd@163.com |
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| Abstract
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| [Objective] To investigate the effect of SolutolHS 15 (Sol) on corneal preparation rate and to explore their use in ophthalmology. [Methods] The effects of Sol on the corneal permeability for Baicalin were investigated in vitro with isolated corneas of rabbit. [Results] The 0.4% and 0.8% Sol could increase the appeared permeability for Baicalin as much as 2.05 and 1.65 times respectively when compared with the permeability in control(P<0.05). However, 0.2%, 1.0% and 2.0% Sol could not improve the appeared permeability for Baicalin(P>0.05). [Conclusion] The 0.4% and 0.8% Sol can enhance the corneal appeared permeability for Baicalin significantly and have not irritation on eye tissues. |
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