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| The effect of the Houhai acupoint acupuncture on learning and memory ability as well as the synaptic protein expression and neuronal ultrastructure of the hippocampus CA1 region in vascular dementia rat |
| Hits 2034 Download times 2009 Received:December 09, 2012 |
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| DOI
10.11656/j.issn.1673-9043.2013.02.07 |
| Key Words
Houhai acupoint;vascular dementia;learning and memory ability;SYN;ultrastructure |
| Author Name | Affiliation | E-mail | | ZHANG Xue-jun | Fujian University of TCM, Fuzhou 350122, China | | | LIU Jing | Zigong TCM Hospital, Zigong 643000, China | | | LIN Yu-fang | The First Hospital of Fuzhou, Fujian 350009, China | | | LIN Ru-hui | Fujian University of TCM, Fuzhou 350122, China | | | LIN Dong | Fujian University of TCM, Fuzhou 350122, China | | | CHEN Cai-yi | Fujian University of TCM, Fuzhou 350122, China | | | WU Qiang | Fujian University of TCM, Fuzhou 350122, China | wq2033@yahoo.com.cn |
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| Abstract
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| [Objective] To study the effect of Houhai acupoint acupuncture on the learning and memory function of rat which suffers from vascular dementia as well as on the synaptic protein expression and neuronal ultrastructure of hippocampus' CA1 region. [Methods] Forty eight rats were randomly divided into blank group, model group and acupuncture group, Rat VD models established by permanent occlusion of the bilateral common carotid artery, then acupuncture Houhai acupoint for three courses of treatment, Morris water maze was used to assess their learning and memory ability, the change of the hippocampal tissue was studied with immunohistochemistry and transmission electron microscope. [Results] Learning and memory ability scores of acupuncture group, and area synaptic grain protein expression hippocampal CA1 of had the significant difference(P<0.05) compared with blank group. Nerve cell encapsulated, euchromatin in the nucleus were evenly distributed. There were many mitochondria without obvious breakage or missing and abundant rough endoplasmic reticulum;there were a few glial cells, no obvious swelling, tearing and dissolution of myelin. There was micro-filament microtube, abundant mitochondria. [Conclusion] Acupuncture Houhai acupoint can improve vascular dementia rats learning and memory ability, whose mechanism is probably related to improve hippocampal CA1 area synaptic grain protein expression and neurons on ultrastructure. |
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