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| Effect of Chrysophanol on secretion of inflammatory factor from lipopolysaccharide-pretreated microglial cell |
| Hits 2306 Download times 2160 Received:April 02, 2013 |
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| DOI
10.11656/j.issn.1673-9043.2013.03.07 |
| Key Words
Chrysophanol;microglia;inflammatory factor |
| Author Name | Affiliation | E-mail | | JING Hao-ran | Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China | | | YANG Hong-yun | Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China | | | WANG Shao-xia | Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China | wangshaoxia1978@hotmail.com | | CHEN Di-di | Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China | | | SUN Xue-mei | Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin Key Laboratory of Chinese Medicine Pharmacology, Tianjin University of TCM, Tianjin 300193, China | |
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| Abstract
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| [Objective] Suppressing the excessive activation of microglia is very important for the treatment of stroke, neurodegenerative and so on. The study is to visit the effects of Chrysophanol on the secretion of inflammatory factor from lipopolysaccharide-induced microglial. [Methods] We cultured microglia cell line, detect the cell viability of microglia and the secretion of nitric oxide(NO), Tumor Necrosis Factor alpha(TNF-α) from lipopolysaccharide(LPS)-induced microglial cell. [Results] Compared with LPS, Chrysophanol could inhibit the secretion of NO and TNF-α. [Conclusion] Chrysophanol can inhibit the LPS-induced secretion of inflammatory factor from microglia. |
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