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Evaluation of extracted art of Rhizoma Picrorhizae based on multiple criteria comprehensively
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DOI   10.11656/j.issn.1673-9043.2013.03.09
Key Words   Rhizoma Picrorhizae;orthogonal test;picroside I;picroside II;percolation
Author NameAffiliationE-mail
HOU Wen-bin Tianjin University of TCM, Tianjin 300193, China
Tianjin Institute of Pharmaceutical Research, Tianjin Engineering Laboratory of Quality Control Technology of TCM, National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine (Tianjin), Tianjin 300193, China 
 
ZHOU Fu-jun Tianjin Institute of Pharmaceutical Research, Tianjin Engineering Laboratory of Quality Control Technology of TCM, National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine (Tianjin), Tianjin 300193, China  
SHAN Qi Tianjin Institute of Pharmaceutical Research, Tianjin Engineering Laboratory of Quality Control Technology of TCM, National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine (Tianjin), Tianjin 300193, China  
LIU Chang-xiao Tianjin Institute of Pharmaceutical Research, State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin 300193, China liucx@tjipr.com 
Abstract
    [Objective] To optimize the extraction process of Rhizoma Picrorhizae by an orthogonal experiment and to determine the best extraction parameters. [Methods] The L9(34) orthogonal test was employed based on a multiple criteria comprehensively evaluating the yields of picroside I, picroside II, and total extracts. [Results] The optimum extraction process was characterized as: soaking the crude rhizome powders for 24 h and percolating them with 1.5 mL/min of the flow rate and 16 folds of extraction volume were collected. [Conclusion] The extraction technique is stable and available.This study provides an experimental basis for the industrial production of Rhizoma Picrorhizae.

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