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Literature analysis on dose of Shenfu injection in treating chronic heart failure
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DOI   10.11656/j.issn.1673-9043.2013.03.12
Key Words   Shenfu injection;chronic heart failure;dose;solvent
Author NameAffiliationE-mail
LIU Chun-xiang Tianjin University of TCM, Tianjin 300193, China  
WANG Yue Tianjin University of TCM, Tianjin 300193, China  
ZHANG Shuo Tianjin University of TCM, Tianjin 300193, China  
ZHANG Li Tianjin University of TCM, Tianjin 300193, China  
XING Dong-mei Tianjin University of TCM, Tianjin 300193, China  
REN Ming Tianjin University of TCM, Tianjin 300193, China renming2008@126.com 
Abstract
    [Objective] To investigate the dose, solvent and solvent-dose of Shenfu injection in treating chronic heart failure. [Methods] The China Full-text Journal Database (CNKI), Jan,1993 to May,2012 was searched, and the clinical studies of Shenfu injection used intravenously for patients with chronic heart failure were found. [Results] The widely used dose of Shenfu injection intravenous infusion in chronic heart failure treatment was within 40~60 mL(80.01%), among them, 50 mL was the most widely applied(35.56%) with better security; 5% dextrose injection as solvent was commonly used(81.11%) and the mostly used dose was 250 mL(55.56%); for patients with diabetes, it was tended to and used 5% dextrose injection or 0.9% saline as solvent add insulin to solvent(50%). [Conclusion] Shenfu injection in therapy for patients with chronic heart failure are mostly applied as drug instruction. However, the research in basic and clinical dose-effect relationship should be strengthened. The optimal safe and effective dose should be explored.

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