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| Effect of four different coating material on drug release property of the Felodipine |
| Hits 2031 Download times 2440 Received:June 20, 2013 |
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| DOI
10.11656/j.issn.1673-9043.2013.03.16 |
| Key Words
felodipine sustaind-release tablets;film coating;drug release;similarity factor |
| Author Name | Affiliation | E-mail | | DU Chao | Tianjin University of TCM, Tianjin 300193, China | | | WANG Yang | Tianjin University of TCM, Tianjin 300193, China | wangysjw@yahoo.com.cn | | YANG Bin | Tianjin University of TCM, Tianjin 300193, China | | | JING Hui-xin | Tianjin University of TCM, Tianjin 300193, China | | | LIU Meng-meng | Tianjin University of TCM, Tianjin 300193, China | | | WANG Li-feng | Tianjin University of TCM, Tianjin 300193, China | |
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| Abstract
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| [Objective] To study the effect of four different coating materials on the drug-release properties of the felodipine. [Methods] The hardness, friability and hygroscopicity of the different sustained-release tablets of coating materials were determined. The type and weight gain of the coating materials, the pattern combined with scanning electron microscope were screened through quality standards of felodipine sustained-release tablets release method according to the indicator of the similarity factor f2 value. [Results] The f2 value was 56.01. It was determined that the Opadry Ⅱtype was the coating material of the felodipine sustained-release tablet. All of the following results met the requirements: the weight gain of coating is 2%, hardness is 109.11 N, friability is 0.46% and hygroscopic percent weight gain is 0.16%. The result could satisfied the requirement of the Chinese Pharmacopoeia on the in vitro dissolution of the sustained-released preparations Ritger-Peppas model was a better fitting for release kinetics characteristics, the release mechanism of which was the combined action of the drug diffusion and skeleton dissolution according to Peppas equation. [Conclusion] The coating tablet of Opadry Ⅱ has the most similarities with the drug-release properties of the original research drug and it can be applied to the coating materials of the felodipine. |
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