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| Influences of aqueous extract of kelp on immune function and anti-fatigue in mice |
| Hits 2090 Download times 1403 Received:August 15, 2013 |
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| DOI
10.11656/j.issn.1673-9043.2013.04.07 |
| Key Words
aqueous extract of Kelp;immune function;anti-fatigue effect;mice |
| Author Name | Affiliation | | FU Yan-jun | Liaoning University of TCM, Shenyang 110847, China | | ZHANG Xiao-yu | Liaoning University of TCM, Shenyang 110847, China |
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| Abstract
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| [Objective] To observe the influences of aqueous extract of Kelp（AEK） on immune function and anti-fatigue in Mice.[Methods] Mice（18～22） g were divided into 4 groups: low dose group（AEK 21.2 g/kg）, high dose group （AEK 106 g/kg）, blank control group（0.9% NaCl）, positive control group（thyroxine 20 mg/kg）. Drugs were administered to mice by i.g. for 10 days. The phagocytic activity of peritoneal macrophages, transformation of lymphocyte, the production of serum haemolysis and skin delayed-type hypersensitivity reaction induced by DNCB were determined. Anti-fatigue effect was evaluated by the swimming time in water. [Results] AEK could improve phagocytic activity of peritoneal macrophages and transformation of lymphocyte, and promote mouse skin delayed-type hypersensitivity reaction induced by DNCB as well as increase production of the haemolysis. Swimming time was prolonged by AEK. [Conclusion] Non-specific, cellular and humoral immunity is promoted, and anti-fatigue effect is increased by AEK in mice. |
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