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| Acupuncture influence to mitochondria calcium Ions’ concentrations and reactive oxygen species of SAMP8 mouse |
| Hits 2226 Download times 1441 Received:August 11, 2013 |
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| DOI
10.11656/j.issn.1673-9043.2013.04.08 |
| Key Words
AD;acupuncture;mitochondria;ROS;calcium ions |
| Author Name | Affiliation | | HAO Ting-ting | Tianjin University of TCM Tianjin 300193, China | | FU Yu | Tianjin University of TCM Tianjin 300193, China | | XIN Jing | Tianjin University of TCM Tianjin 300193, China | | GUO Rui-jing | The First Teaching Hospital of Tianjin University of TCM Tianjin 300193, China | | LIU Yu-jing | The Second Affiliated hospital of Heilongjiang University of Chinese Medicine Harbin 150009, China |
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| Abstract
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| [Objective] To discuss the acupuncture adjusting function to mitochondria calcium ions' concentration and reactive oxygen species of SAMP8 mouse. [Methods] Chose SAMP8 mouse and normal control SAMR1 as experimental subjects, with"tri-jiao acupuncture method" (the old name were nourishing-regulating qi acupuncture method) and marking method of fluorescent indicator and fluorescence probe, to observe the acupuncture influence to mitochondria calcium ions' concentrations of mouse' cortex hippocampus and reactive oxygen species. [Results] Combined with control group, mitochondria calcium ions' concentration of mouse' cortex and hippocampus in SAMP8 group was up-regulated, of which the acupuncture group was down-regulated to the control group and the non-acupoints group was up-regulated with significant difference. [Conclusion] It could obviously restrain the accumulation of mitochondria calcium ions and reduce the generation of oxygen radical by acupuncture. Meanwhile, acupuncturing at non-acupoints could produce harmful stimulation and accelerate oxidative damage. |
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