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| Aqueous Extract of psoralea corylifolia induced liver injury in rats |
| Hits 2211 Download times 2033 Received:September 07, 2013 |
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| DOI
10.11656/j.issn.1673-9043.2013.04.09 |
| Key Words
Psoralea corylifolia;aqueous extract;rat;liver injury |
| Author Name | Affiliation | | ZHOU Kun | Institute of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China | | DAI Zhi | R&D Center of Sanjiu Medical & Pharmacutical CO. LTD, Shenzhen 518110, China | | LIU Zhan-biao | Institute of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China | | WANG Yue-fei | Institute of Traditional Chinese Medicine, Key Laboratory of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the liver injury induced by aqueous extract of Psoralea corylifolia in rats. [Methods]Rats were intragastrically treated with Psoralea corylifolia and its aqueous extract for 12 weeks. Serum biochemical indices were determined. Liver weight and liver coefficient were measured. Histopathological examination for the liver was also performed with light microscopy. To compared HPLC chromatograms of Psoralea corylifolia and its aqueous extract and to determine the main composition of aqueous extract. [Results] Rats of Psoralea corylifolia 2.10 g/kg, 1. 05 g/kg groups and the aqueous extract 2.10 g/kg group were hepatomegaly, and its liver coefficient increased significantly. There were local diffuse hepatic steatosis in 3 rats of Psoralea corylifolia 2.10 g/kg group and 2 rats of aqueous extract 2.10 g/kg group. Aqueous extract of Psoralea corylifolia mainly contain psoralenoside, isopsoralenoside, psoralen and isopsoralen. [Conclusion] Aqueous extract of Psoralea corylifolia induced liver injury in rats. Psoralenoside, isopsoralenoside, psoralen, isopsoralen have hepatotoxicity. |
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