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| Effect of Tanreqing on radiation-induced lung injury and expression of TGF-β1 |
| Hits 1967 Download times 1782 Received:October 20, 2013 |
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| DOI
10.11656/j.issn.1673-9043.2014.01.05 |
| Key Words
radiation-induced lung injury;Tanreqing;TGF-β1 |
| Author Name | Affiliation | | DUAN Xin-bo | Hebei Provincial People's Hospital, Shijiazhuang 050000, China | | LIU Wei | Hebei College of TCM, Shijiazhuang 050017, China | | XU Xin | Hebei Provincial People's Hospital, Shijiazhuang 050000, China |
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| Abstract
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| [Objective] To observe the effect of intervention with Tanreqing on radiation-induced lung injury and the level of expression of the TGF-β1. [Methods] Seventy cases of radiotherapy in patients with lung cancer were randomly divided into the control group and the treatment group. Routine conventional radiotherapy was given in the control group, while in the treatment group except for radiotherapy the patients were also treated with Tanreqing injection, 20 mL adding into 250 mL of the intravenous infusion of 5% glucose injection, once a day with 15~30 d as a course. We compared the incidence of radiation-induced lung injury between two groups by determination of plasma TGF-β1 before and after treatment. [Results] Difference of plasma TGF-β1 content between two groups after treatment was statistically significant (P<0.001); Difference of total incidence of acute radiation pneumonitis and severity of radiation pneumonitis between two groups were also statistically significant (P<0.05) without significant adverse drug reactions. [Conclusion] Tanreqing can inhibit plasma TGF-β1 over-expression after radiation therapy and can effectively reduce the incidence of radiation-induced lung injury. It is worthy of popularization and application in the treatment of lung cancer and other chest radiation oncology. |
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