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| Effect of Xinnao Shutong and its monomer on Lipopolysaccharides activated microglia cells |
| Hits 2114 Download times 1952 Received:September 28, 2013 |
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| DOI
10.11656/j.issn.1673-9043.2014.01.07 |
| Key Words
Xinnao Shutong;NO;inflammatory mediators;microglial cell |
| Author Name | Affiliation | E-mail | | LU Guo-yan | Key Laboratory of Tianjin University of TCM, State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chinese medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin 300193, China | | | YANG Hong-yun | Key Laboratory of Tianjin University of TCM, State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chinese medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin 300193, China | | | WANG Shao-xia | Key Laboratory of Tianjin University of TCM, State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chinese medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin 300193, China | | | HU Li-min | Key Laboratory of Tianjin University of TCM, State Key Laboratory of Modern Chinese Medicine, Tianjin Key Laboratory of Chinese medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin 300193, China | huliminth@126.com |
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| Abstract
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| [Objective] To study the effects of Xinnao Shutong and its monomer composition on microglia (BV-2) and its mechanism. [Methods] The experiment was divided into control group, lipopolysaccharide(LPS) group, dosing group. The effect of Xinnao Shutong (different dilution multiples of Xinnao Shutong and its monomer composition) on cellular activity and the production of nitric oxide (NO) in microglia cell induced by lipopolysaccharide (LPS). [Results] Xinnao Shutong could not significantly inhibit the microglia in releasing NO induced by LPS. Among the 13 kinds of monomer composition of Xinnao Shutong, Pseudoprotodioscin, Gitogenin, Diosgenin could inhibit NO secretion without affecting the cell vitality. [Conclusion] Some monomer composition of Xinnao Shutong can inhibit the releasing of NO in activated microglia. It may be one of the mechanisms of neural protection. |
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