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| Studies on nasal gel of Berberine Hydrochloride |
| Hits 2267 Download times 2079 Received:September 16, 2013 |
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| DOI
10.11656/j.issn.1673-9043.2014.01.12 |
| Key Words
berberine hgdrochloride;carbopol;nasal gel;drug release |
| Author Name | Affiliation | E-mail | | WANG Li-feng | Experimental Teaching Administration Department, Tianjin University of TCM, Tianjin 300193, China | | | ZHANG Si-pei | College of TCM, Tianjin University of TCM, Tianjin 300193, China | | | CAO Ying | Experimental Teaching Administration Department, Tianjin University of TCM, Tianjin 300193, China | | | GUO Da-liang | College of TCM, Tianjin University of TCM, Tianjin 300193, China | 13920632603@126.com |
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| Abstract
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| [Objective] To design a kind of nasal gel of berberine and inspect the quality of it in vitro. Nasal administration is a new way to deliver drugs to the brain. The drug can transport into cerebrospinal fluid after nasal drops to treat Neurodegenerative diseases. [Methods] In order to optimize the prescription the orthogonal design was carried out. The experiment used Cabarbopol-980 as gel base, triethanolamine as pH and viscosity adjuster, and glycerin as cosolvent. The release of berberine from nasal gel was determined by UV and the curve was fitted by Weibull model. [Results] The optimum nasal gel was made by Carbopol-980 0.1%, berberine 1%, appearance pH was adjusted to 6.0～7.0, the average viscosity was about 1 200 mPa·s. The release curve of berberine fitted by Weibull showed that Td was 104.8 min. [Conclusion] Using bioadhesive material carbopol-980 to make nasal gel of berberine is easy to operate and control. The release of berberine is stable. |
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