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| Influence of Corydalis before and after processing in compound Jinlingzisan on smooth muscle of small intestine of rats |
| Hits 1785 Download times 2167 Received:November 23, 2013 |
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| DOI
10.11656/j.issn.1673-9043.2014.02.08 |
| Key Words
Jinlingzisan;Corydalis;smooth muscle of small intestine;spasmolysis;processing |
| Author Name | Affiliation | E-mail | | LI Jing-jing | Tianjin Chinese Medicine Factory Co. Ltd, Tianjin 300100, China | | | NIU Yan-bing | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | SHI Ning | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YANG Sheng-cai | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WU Tian-ze | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CAI Qing-qing | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | FENG Ya-ru | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIANG Shu-xin | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | DOU Zhi-ying | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | zhiyingdou@163.com |
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| Abstract
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| [Objective] To observe the influence of corydalis and vinegar corydalis after compatibility with Szechwan Chinaberry Fruit respectively on the contractile activity of smooth muscle of isolated small intestine in rats. [Methods] The smooth muscle of small intestine of Wistar rats was isolated for observing the effect of corydalis before and after compatibility with Szechwan Chinaberry Fruit on the spontaneous activity of the smooth muscle of the isolated small intestine, contraction evocated by acetylcholine (Ach) and relaxation evocated by atropine. [Results] Taking the change of tension as index, the high-dose, middle-dose and low-dose of corydalis and vinegar corydalis after compatibility with Szechwan Chinaberry Fruiit respectively had an inhibitory effect on the spontaneous activity of smooth muscle, and the function of vinegar corydalis after compatibility with Szechwan Chinaberry Fruit had more obvious spasmolysis. In addition, it had obviously antagonism effect on the contraction of smooth muscle of small intestine evocated by Ach in rats. What's more, both corydalis and vinegar corydalis had synergistic effect for the relaxation evocated by atropine. [Conclusion] Corydalis and vinegar corydalis after compability with Szechwan Chinaberry Fruit have an inhibitory effect on smooth muscle of the isolated small intestine in rats, and the improvement of high-dose of vinegar corydalis applied to compound is better than corydalis in compound on smooth muscle of isolated small intestine in rats. |
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