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| Establishment and evaluation on model of diabetic foot infected by staphylococcus aureus in rats |
| Hits 1879 Download times 2014 Received:January 25, 2014 |
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| DOI
10.11656/j.issn.1673-9043.2014.03.06 |
| Key Words
staphylococcus aureus;infections;diabetic foot;rats;models |
| Author Name | Affiliation | E-mail | | HAN Qiang | Shuguang Hospital Affiliated of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China | | | LI Shou-wei | Hangzhou Xiaoshan District Hospital of Traditional Chinese Medicine, Hangzhou 311201, China | pengyang2013@163.com | | LIU Guo-bin | Shuguang Hospital Affiliated of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China | drliuguobin@163.com | | CHEN Jun-hao | Shuguang Hospital Affiliated of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China | |
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| Abstract
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| [Objective] To establish and evaluate the model of diabetic foot infected by staphylococcus aureus in rats.[Methods] Based on the description about the establishment of the model of diabetic foot form the data in existing literature, combined with the clinical observation, high-fat diet with streptozotocin (STZ) was used to establish diabetes. Then constant temperature and pressure were given to establish ulcers. With a phased implementation of the modeling factors and a comprehensive evaluation method with integrated disease and syndrome a model of diabetic foot infected with staphylococcus aureus was initially established in rats. [Results] When compared between the model control group (M) and the model treatment group (MT) it was fond that HCRP, NO, AGES, TNF-α, NF, IL-1β, were different (P<0.05) with a lower levels in the treatment group. [Conclusion] A reliable tool is provided for studying infected diabetic foot with this model. |
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