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| Study on preparation of cubic liquid crystalline nanoparticles of salvianolic acid B and intestinal absorption in situ in rats |
| Hits 1987 Download times 1427 Received:January 15, 2014 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2014.03.14 |
| Key Words
salvianolic acid B;cubic liquid crystalline nanoparticles;intestinal absorption |
| Author Name | Affiliation | E-mail | | GUO Xiu-jun | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Zhi-dong | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | lonerliuzd@163.com | | HUANG Yu | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | PANG Xiao-chen | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | QU Ji-lan | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HAN Zhen-zhen | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To prepare salvianolic acid B-loaded cubic liquid crystalline nanoparticles（sal-B LCN） and investigate the intestinal absorption character in situ in rats. [Methods] The nanoparticles were prepared using high-pressure homogenization. The prescription were optimized with drug size and entrapment efficiency were served as indexes. It爷s morphology was examined by transmission electron microscope and single pass perfusion method was used for its intestinal absorption character in situ in rat. [Results] The size of the nanoparticles was (172.2±5) nm, the zeta was (-14.8±2) mV and the entrapment efficiency was (38.6±3)%. The result suggested that sal-B solution and sal-B LCN could be absorbed at each intestinal segment and all the two preparations showed a maximum absorptions at the duodenum. The intestinal absorption of sal-B LCN was better than sal-B solution (P<0.05). [Conclusion] Sal-B LCN can improve the intestinal absorption of sal-B in rats. |
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