|
| Effects of Yiqi Tongluo formula on cell apoptosis and the expression of anti-Oxidant of HO-1 in sciatic nerve on diabetic peripheral neuropathy |
| Hits 1691 Download times 1329 Received:March 05, 2014 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2014.04.08 |
| Key Words
diabetic peripheral neuropathy;cell apoptosis;sciatic nerve |
| Author Name | Affiliation | E-mail | | CHANG Geng | Department of Neurology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China | | | SUN Da-yong | Department of Neurology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China | | | CHANG Feng-yun | Hebei Medical University, Shijiazhuang 050091, China | | | SUN Xiao-pei | Department of Neurology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China | | | HAN Jie | Department of Neurology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China | hjj.427@163.com |
|
| Abstract
|
| [Objective] To discuss the effects of Yiqi Tongluo formula on rats with diabetic peripheral neuropathy(DPN) and explore its potential mechanisms.[Methods] The rat model of DPN was induced by intraperitoneal injection of streptozotocinith, and DPN rats were divided into treatment group treated with daily Yiqi Tongluo formula for eight weeks. The expression of LDH, Bax, Caspase-3 and the number of cell apoptosis in the sciatic nerve were evaluated and compared.[Results] Compared with the model group, the number of apoptotic cells and the expression of LDH, Bax, Caspase-3 were lower in the Yiqi Tongluo group in rat sciatic nerve, while the expression of HO-1 is higher significantly.[Conclusion] Yiqi Tongluo formula can effectively increase the expression of HO-1, inhibit the oxidative damage and reduce cell apoptosis in sciatic nerve. |
|
|
|
|
|
