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| Optimization of Chonghe gel formulation using Plackett-Burman design and single-factor design |
| Hits 1730 Download times 2541 Received:March 11, 2014 |
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| DOI
10.11656/j.issn.1673-9043.2014.04.10 |
| Key Words
Plackett-Burman design;Chonghe gel;formulation optimization |
| Author Name | Affiliation | E-mail | | WANG Yan-ming | Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China
Harbin Medical University(Daqing), Daqing 163319, China | | | DU Shou-ying | Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | WANG Ya-jing | Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | yajing022@163.com | | ZHANG De-qin | Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | | | SUN Shi-zhen | Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To choose the optimal formulation for the Chonghe gel prescription.[Methods] The viscosity of the preparation and the stability of paeoniflorin and osthole were served as evaluation criterions. The experiment would inspect the significance of influential factor of preparation by Plackett-Burman design. Then the prescription was further optimized for those factors.[Results] Plackett-Burman design tests showed that the amount of Carbomer, drug loading, glycerol, pH value were significant influencing factors on the formulation viscosity. The amount of sodium bisulfite, pH value were major influencing factors of stability of paeoniflorin. By further optimization of the various factors, the final prescription was optimized as follows:carbomer 981 was 1.5%, glycerol was 12%, sodium bisulfite was 0.175%, pH value was at 4.5 to 6.0 adjusting by the triethanolamine, the amount of the drug loading was 20% to 30%.[Conclusion] The optimized formulation is proved to be reliable, stable and available for meeting the preparation requirements. |
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