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| Clinical observation of Tang Tongyin prescription in TCM for patients with early diabetic nephropathy |
| Hits 2132 Download times 1829 Received:May 24, 2014 |
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| DOI
10.11656/j.issn.1673-9043.2014.05.04 |
| Key Words
Tang Tongyin in TCM;early stage of DN;VEGF;proteinuria |
| Author Name | Affiliation | | WANG He-qiang | Taiping People's Hospital of Dongguan, Dongguan 523900, China
Rehabilitation Hospital of Dongguan, Dongguan 523119, China | | ZHANG Tai-kun | Taiping People's Hospital of Dongguan, Dongguan 523900, China | | FU Ying | Taiping People's Hospital of Dongguan, Dongguan 523900, China | | LIAO Xin-qian | Taiping People's Hospital of Dongguan, Dongguan 523900, China | | ZHOU Yong | Taiping People's Hospital of Dongguan, Dongguan 523900, China | | DENG Gan-lin | Taiping People's Hospital of Dongguan, Dongguan 523900, China | | DENG Shao-qi | Taiping People's Hospital of Dongguan, Dongguan 523900, China |
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| Abstract
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| [Objective] To observe the influence of traditional Chinese medicine Tang Tongyin(TTY)on indexes of patients with early diabetic nephropathy, evaluate the drug safety and reliability of the prescription system clinically, quantitatively evaluate the clinical effect in treating diabetic nephropathy(DN)and explore its possible mechanism for providing a safe, economic, effective prescription of TCM in preventing and treating DN.[Methods] The 100 patients were randomly divided into two groups treating everyone with corresponding methods: the control group(50 cases)and the treatment group (50 cases). At the same time the indicators of patients were detected before and after treatment. [Results] After treatment, BRT, SRT, URT, AST, ALT, ALP, TBIL, IBIL, DBIL, Scr, BUN and GGT of two groups were not changed(P>0.05). VEGF, Alb/Cr, HbA1c, FBG, 2HBG and Insulin of two groups were decreased after treatment when compared with that of before treatment. However, Ccr was increased after treatment compared with that before treatment(P<0.05 or P<0.01). The VEGF, Alb/Cr, FBG, 2HBG, HbAlc and insulin of the treatment group were less than that of the control group. Ccr of the treatment group was increased compared with that of the control group(P<0.05).[Conclusion] TTY is safe and reliable, and it has protective some effects against kidney injury in patients with early stage DN, which is worth promoting clinically. |
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