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| Evaluation of efficacy of Jiedu Huayu Tongfu granule on advanced pancreatic cancer patients with damp-heat and stasis-toxic syndrome |
| Hits 1917 Download times 1557 Received:April 28, 2014 |
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| DOI
10.11656/j.issn.1673-9043.2014.05.05 |
| Key Words
Jiedu Huayu Tongfu granule;advanced pancreatic cancer;clinical study |
| Author Name | Affiliation | | DAI Ling-ling | The Third Oncology Department, Hospital of Traditional Chinese Medicine in Yantai city, Yantai 264001, China |
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| Abstract
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| [Objective] To observe the clinical curative effect of Jiedu Huayu Tongfu granule in the treatment of the Damp-heat and Stasis-toxic advanced pancreatic cancer. [Methods] The 50 patients were randomly divided into 2 groups, 25 patients in treatment group were based on gemcitabine, and Jiedu Huayu Tongfu granule, control plus placebo group of 25 patients treated with chemotherapy. The two groups were treated for 4 courses, 21 days are 1 treatment course, observe its curative effect and TCM symptom improvement, index function of T cell subsets of CD3+, CD4+, CD4+/CD8+ and NK cell immunity, tumor markers CEA, CA199, and coagulation series (PT-T, APTT-T, D2 dimer and platelet (PLT)index. [Results] In the treatment group, curative effect in complete remission (CR)was 0 cases, and partial remission (PR)was 18 cases, the total efficiency of 72%. In control group, CR was 0 cases; PR was 15 cases, and the total effective rate was 60%, no significant difference (P>0.05). In treatment group, the clinical symptoms improved rate was 24%, total efficiency of 84%. In control group significantly improved rate was 8%, the total efficiency of 56%, and the difference was statistically significant (P<0.05). CD3+, CD4+, CD4+/CD8+ and NK cells of the treatment group were in creased, compared with that before treatment, and were higher than that in the control group, and the difference was statistically significant (P<0.05). In the two groups before and after treatment, CEA, CA199 were no statistically significant difference (P>0.05). PT, APTT,D2 dimer and PLT in treatment group were lower than those before therapy, and lower than that of control group. The difference was statistically significant (P<0.05). The incidence of adverse reaction was lower than that control group. [Conclusion] Jiedu Huayu Tongfu Granule has better effect and safety on the patients with advanced pancreatic cancer. |
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