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| Protective effects of Danhong injection on DPPH-induced injuries in the isolated hearts of rats |
| Hits 2091 Download times 1748 Received:April 26, 2014 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2014.05.08 |
| Key Words
Danhong injection;DPPH;isolated hearts;Langendorff |
| Author Name | Affiliation | E-mail | | DUAN Zhen-zhen | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae of Ministry of Education, Tianjin 300193, China | | | YU Jia-hui | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae of Ministry of Education, Tianjin 300193, China | | | LI Yu-hong | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae of Ministry of Education, Tianjin 300193, China | yhltcm@126.com | | LIU Xuan | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae of Ministry of Education, Tianjin 300193, China | | | JIA Ming-xian | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin Key Laboratory of Traditional Chinese Medicine Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae of Ministry of Education, Tianjin 300193, China | |
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| Abstract
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| [Objective] To examine the protective effects of Danhong injection on DPPH-induced myocardial injuries in the isolated hearts of rats in Langendorff model. [Methods] The isolated hearts of rats were perfused in a Langendorff model for 30 min and pre-treatment with Danhong injection for 10 min. The hearts were subjected to Krebs-Henseleit(K-H)solution with DPPH 0.25 μmol/L for 10 min to cause myocardial dysfunction, and followed by 10 min recovery with K-H solution. The perfusion pressure(PP), left ventricular systolic pressure(LVSP), left ventricular end diastolic pressure (LVEDP), heart rate (HR), maximal and minimum rate of pressure development(±dp/dtmax)were recorded. And the heart rate pressure product (RPP)was calculated. [Results] The perfusion pressure significantly decreased after 10 min perfusion with Danhong injection. Perfusion with DPPH causes a remarkable decrease in RPP, +dp/dtmax and an increase in -dp/dtmax. Pretreatment with Danhong injection of 2.5 μL/mL and 5 μL/mL for 10 min significantly reduced the DPPH-induced myocardial injuries. [Conclusion] Danhong injection can dilate coronary artery and protect against the myocardial injuries induced by DPPH in isolated rat hearts. |
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