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| Meta analysis of randomized controlled trials for treatment of rheumatoid arthritis by Biqi capsule |
| Hits 1992 Download times 1877 Received:August 12, 2014 |
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| DOI
10.11656/j.issn.1673-9043.2014.06.05 |
| Key Words
Biqi capsule;rheumatoid arthritis;Meta analysis |
| Author Name | Affiliation | E-mail | | YANG Yan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | FAN Lin-lin | Tianjin Medical University, Tianjin 300070, China | | | GU Li-li | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Hong-wu | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Peng | Tianjin Medical Information Institute, Tianjin 300070, China | | | ZHENG Fang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | zhengFang_1979@163.com |
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| Abstract
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| [Objective] To systemically assess the therapeutic effect and safety of Biqi capsule in treating rheumatoid arthritis and provide some scientific evidences for its clinical application and promotion.[Methods] Firstly, searching,collecting and screening the randomized controlled trials of Biqi capsule for rheumatoid arthritis treatment. Secondly, the quality of the included trials was assessed using the Jadad scale. Finally, Meta analysis was performed using the Software RevMan 5.2.5 to systemically evaluate the included studies. [Results] Ten articles were included in this study. All of them were domestic studies with a Jadad scale less than 3, the 477cases were cumulated in the treatment group and 409 cases control group. Combined analyses showed that the clinical effects of the treatment group were better than that in control group (Z=6.46, P<0.000 1). The effect on reducing erythrocyte sedimentation rate(ESR) and rheumatoid factor (RF) were more obvious in treatment group. Security analysis indicated that less adverse reactions were occurred in treatment group (Z=4.15, P<0.000 1).[Conclusion] The evidence indicates that Biqi capsule has exact effects and preferably security in treating rheumatoid arthritis. Duo to that the quality of these included studies were low, so these conclusions need to be interpreted carefully and the high quality of randomized controlled trails with large sample were needed to confirm the conclusion. |
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