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| Study on acute toxicity test of Wutian Hepatoprotective Liquid |
| Hits 1645 Download times 1756 Received:September 26, 2014 |
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| DOI
10.11656/j.issn.1673-9043.2015.01.08 |
| Key Words
Wutian Hepatoprotective liquid;acute toxicity test;median lethal dose test;the maximum dose test |
| Author Name | Affiliation | E-mail | | LIU Jian-wei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | BI Ye-dong | Tianjin Binhai New Area of Hangu Hospital of Traditional Chinese Medicine, Tianjin 300380, China | byd00933@163.com | | FAN Ying-chang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | JIANG Xi-juan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GAO Qing | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GUO Mao-juan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | SU Jin-ling | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] Clear safety dose range of Wutian hepatoprotective liquid, to provide the experimental basis for the clinical medication safety.[Methods] On the basis of acute toxicity of natural drug testing technology guidelines for research design, to observe the acute toxicity in mice, and record the death, to determine the acute toxicity test of Wutian Hepatoprotective liquid median lethal dose (LD50) or the maximum dose. [Results] The median lethal LD50 hadn't been measured in the experiment, and the maximum dose of the experimental mice had maximum dose equivalent 228g/(kg·d), equivalent to the adult clinical use of the drug 120 times. [Conclusion] The liver protecting medicine "Wutian Hepatoprotective liquid" has low acute toxicity reaction, commonly used in clinical drug safety. |
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