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| Study on the antidepressant effect of Duzhongwan with different proportions |
| Hits 2056 Download times 1733 Received:August 24, 2014 |
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| DOI
10.11656/j.issn.1673-9043.2015.01.10 |
| Key Words
Duzhongwan;depression;forced swimming test;tail suspension test;SAMP6 mice |
| Author Name | Affiliation | E-mail | | DUAN Wei-hua | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YU Jia-hui | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GAO Xiu-mei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | yanjiuyuanbangongshi@gmail.com |
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| Abstract
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| [Objective] To study the antidepressant effect of Duzhongwan with different proportions. [Methods] Three months old SAMP6 mice and their normal control mice SAMR1 were enrolled in this study. The SAMP6 mice were treated with high and low dose of Duzhongwan, respectively, contrasting with Duzhong and Xuduan during 12 weeks. At 1h after the administration(ig), the open field test (OFT), the tail suspension test (TST) and the forced swimming test (FST) were used to observe the antidepressant effect of Duzhongwan with different proportions. [Results] The immobility time of SAMP6 mice in Duzhongwan low dose group could significantly reduce in FST and TST,compared with those in the control group(P<0.05 or P<0.01). [Conclusion] The results suggested that Duzhongwan performed antidepressant effect. |
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