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| Protective effect of Salvianolic acid B on nerve cells after cerebral injury |
| Hits 2146 Download times 1484 Received:August 28, 2014 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2015.01.16 |
| Key Words
Salvianolic acid B;brain damage;neuroprotective |
| Author Name | Affiliation | E-mail | | MA Meng-meng | Tianjin Laboratory of Chinese Medicine Pharmacology, Tianjin Laboratory of modern Chinese medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GUO Hong | Tianjin Laboratory of Chinese Medicine Pharmacology, Tianjin Laboratory of modern Chinese medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Han | Tianjin Laboratory of Chinese Medicine Pharmacology, Tianjin Laboratory of modern Chinese medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Qiao-yue | Tianjin Laboratory of Chinese Medicine Pharmacology, Tianjin Laboratory of modern Chinese medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HU Li-min | Tianjin Laboratory of Chinese Medicine Pharmacology, Tianjin Laboratory of modern Chinese medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | huliminth@126.com |
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| Abstract
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| In recent years, studies have shown that Salvianolic acid B play a protective role on damaged nerve cells.The mechanism includes promoting the stem cells proliferation and differentiation, maintaining intracellular calcium homeostasis and mitochondrial membrane potential, inhibiting inflammatory reaction, reducing free radicals,regulating expression of apoptosis-related genes and related neurotransmitter as well as regulating PI3K/Akt/GSK-3β, AK2/STAT3 pathway an so on. With its further research, there is hope for the treatment of cerebral ischemia, neuropathy and other diseases. |
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