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| Comparative studies on pharmacological effects of compound erigeron headache tablet with different extraction techniques |
| Hits 1886 Download times 1403 Received:October 25, 2014 |
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| DOI
10.11656/j.issn.1673-9043.2015.02.09 |
| Key Words
extraction technique;compound erigeron headache tablet;migraine;mice models;analgesic |
| Author Name | Affiliation | E-mail | | WANG Ya-fei | School of Science, Tianjin University, Tianjin 300072, China | | | FENG Xia | School of Science, Tianjin University, Tianjin 300072, China | f_x@tju.edu.cn.com | | MA Li | Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine (Tianjin), Tianjin 300193, China | zhihua504@163.com | | HAN Feng | Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine (Tianjin), Tianjin 300193, China | | | GAO Jing | Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine (Tianjin), Tianjin 300193, China | | | DENG Jin-li | School of Science, Tianjin University, Tianjin 300072, China | |
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| Abstract
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| [Objective] To compare pharmacological properties of different extracts of compound erigeron headache tablet and to select the optimum extracting technique. [Methods] The method of acetic acid twisting and thrilling test were adopted in the research of analgesic effect, one mice migraine model was induced by nitroglycerin(10 mg/kg) and the other was duplicated by subcutaneous injection of reserpine, and then were treated with the extracts of compound. [Results] The extracts of compound erigeron headache tablet could significantly prolong the latency of thrilling, also could decrease the number of twisting, and had an obvious analgesic effect, the alcohol extracts in high dosage group were more effective than the others. The experiments of therapeutical effect showed that the alcohol extracts could both reduce the number of scratching. Water extracts and alcohol-water extracts only worked in high dosage group(P<0.05). The extracts could significantly increased 5-HT level, and the alcohol extracts group were more effective than the others. [Conclusion] The pharmacological effects of alcohol extracts are better than the other two in the same dose, the extraction method of alcohol is the optimum extraction technique. It is worth further researching and developing. |
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