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| Optimization of extraction technology for Chaihu Guizhi granule by multi-index comprehensive evaluation method |
| Hits 1836 Download times 1715 Received:November 23, 2014 |
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| DOI
10.11656/j.issn.1673-9043.2015.02.11 |
| Key Words
Chaihu Guizhi granule;orthogonal test;extraction technology;Saikosaponin A;baicalin;paeoniflorin |
| Author Name | Affiliation | E-mail | | HAN Zhong-yao | Qiannan Medical College for Nationalities, Duyun 558000, China | | | ZHOU Fu-jun | Tianjin Institute of Pharmaceutical Research, Tianjin 3001933, China | | | LIU Fang | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HOU Wen-Bin | Tianjin Institute of Pharmaceutical Research, Tianjin 3001933, China | houwb@tjipr.com |
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| Abstract
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| [Objective] To optimize extraction process of prescription drugs from Chaihu Guizhi Granule by orthogonal test.[Methods] Ethanol extraction technology of Radix bupleurl and other herbs was optimized by orthogonal test with Saikosaponin A, baicalin, paeoniflorin and extract rate as detection index.[Results] Optimum extraction process conditions were determined as follows: Radix bupleurl and other herbs were extracted 3 times with 2 h by 10 times the amount of 80% ethanol.[Conclusion] This optimized extraction technology of Chaihu Guizhi Granule was stable and feasible, it could be extended to industrial production. |
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