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Intervention of Sangxian Jiangya granule on VEGF and NM23 of spontaneously hypertensive rats
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DOI   10.11656/j.issn.1673-9043.2014.07
Key Words   spontaneously hypertensive rats;Sangxian Jiangya granule;VEGF;nm23
Author NameAffiliation
ZHANG Yun-hui Shandong University of Traditional Chinese Medicine, Jinan 250014, China 
Abstract
    [Objective] To observe effect of Sangxian Jiangya granule on myocardial vascular endothelial growth factor(VEGF)and nm23, and to discuss the intervention of Sangxian Jiangya granule on the growth and inhibition factor of vascular endothelial cell.[Methods] Spontaneously hypertensive rats were randomly divided into 3 groups: control group, indapamide control group of Western medicine, Sangxian Jiangya group, using Wistar rats as normal control group. After 4 and 8 weeks, myocardial VEGF expression of nm23 was observed. [Results] Compared with the blank control group, in Sangxian Jiangya group the VEGF protein density was markedly increased and nm23 protein density was significantly decreased.[Conclusion] Sangxian Jiangya granule could enhance VEGF expression and decrease nm23 protein density value.

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