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| In vivo study of traditional Chinese medicine Wenyang Tongqiao effect on rat Glioma mechanism |
| Hits 1459 Download times 1881 Received:March 01, 2015 |
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| DOI
10.11656/j.issn.1673-9043.2014.08 |
| Key Words
C6 glioma;Wenyang Tongqiao;SDF-1;CTGF;bFGF |
| Author Name | Affiliation | E-mail | | LI Wen-chang | Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, China | | | SHEN Hong-sheng | Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, China | | | BAI Xue | The Second Hospital Affiliated to Tianjin University of TCM, Tianjin 300150, China | | | FENG Wen-ru | Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, China | | | HU Ren-jie | Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, China | | | ZHOU Jie | The Second Hospital Affiliated to Tianjin University of TCM, Tianjin 300150, China | cnzhoujie@126.com |
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| Abstract
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| [Objective] To study Wenyang Tongqiao traditional Chinese herbal compound inhibition on rat C6 glioma mechanism. [Methods] Put C6 glioma cells in rats with intracranial inoculation, and establish glioma model. Under the MRI (magnetic resonance imaging) conditions the animals were randomly divided into a control group model, Wenyang Tongqiao compound low dose and high dose group. In addition to the control group, the rest of the group was given the corresponding doses of the drug. After three weeks, extract glioma tissue, and use histopathological detection and correlation analysis to detect SDF-1 (stromal cell-derived factor 1), CTGF (connective tissue growth factor), bFGF (basic fibroblast growth factor) indicators. [Results] MRI detected that successfully rat glioma model in vivo tests is constructed. Histopathological observation showed that, compared with control animals, tumor microvessels of animals administered reduce. Visible necrosis of tumor cells, tumor necrosis are more obvious compared with the control group, and the high dose group was slightly stronger. Wenyang Tongqiao administration group SDF-1, CTGF, bFGF compared with the control group showed a decreasing trend.[Conclusion] Wenyang Tongqiao Chinese herbal compound on C6 glioma cell proliferation inhibition indeed, perhaps related to the role of the SDF-1, CTGF, bFGF expression in tumor tissue. |
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