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| Degradation kinetics of Senkyunolide I in Xuebijing injection |
| Hits 2359 Download times 2027 Received:January 15, 2015 |
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| DOI
10.11656/j.issn.1673-9043.2014.09 |
| Key Words
Senkyunolide I;Xuebijing injection;pH;temperature;degradation kinetics |
| Author Name | Affiliation | E-mail | | GAO Jie | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | PU Wei-ling | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | REN Xiao-liang | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | xiaoliang_ren@sina.com | | REN De-fei | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | SUN Li-li | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | QI Ai-di | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To study the degradation kinetic characteristics of Senkyunolide I (Sen I) in Xuebijing injection and aqueous solution under different pH buffer and temperatures.[Methods] HPLC method was established to study the effect on the Senkyunolide I under different pHs and temperatures(65,75,85,95℃). Based on the chemical reaction kinetics and Arrhenius equation, the model of degradation of Sen I and the parameters of degradation kinetics were confirmed.[Results] The results indicated that the degradation of Sen I in aqueous solution and Xuebijing injection conforms to the first-order degradation kinetic. In the injection and aqueous solution, respectively, the energy of activation (Ea) was 177.94 kJ/mol and 194.86 kJ/mol. [Conclusion] Sen I is unstable in alkaline solution and high temperature in both aqueous and Xuebijing injection. Under the same condition, Sen I in Xuebijing injection was more stable than that in aqueous solution. |
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