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Degradation kinetics of Senkyunolide I in Xuebijing injection
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DOI   10.11656/j.issn.1673-9043.2014.09
Key Words   Senkyunolide I;Xuebijing injection;pH;temperature;degradation kinetics
Author NameAffiliationE-mail
GAO Jie College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China  
PU Wei-ling College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China  
REN Xiao-liang College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China xiaoliang_ren@sina.com 
REN De-fei College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China  
SUN Li-li College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China  
QI Ai-di College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China  
Abstract
    [Objective] To study the degradation kinetic characteristics of Senkyunolide I (Sen I) in Xuebijing injection and aqueous solution under different pH buffer and temperatures.[Methods] HPLC method was established to study the effect on the Senkyunolide I under different pHs and temperatures(65,75,85,95℃). Based on the chemical reaction kinetics and Arrhenius equation, the model of degradation of Sen I and the parameters of degradation kinetics were confirmed.[Results] The results indicated that the degradation of Sen I in aqueous solution and Xuebijing injection conforms to the first-order degradation kinetic. In the injection and aqueous solution, respectively, the energy of activation (Ea) was 177.94 kJ/mol and 194.86 kJ/mol. [Conclusion] Sen I is unstable in alkaline solution and high temperature in both aqueous and Xuebijing injection. Under the same condition, Sen I in Xuebijing injection was more stable than that in aqueous solution.

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