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| Isolation and identification of chemical constituents from Eclipta prostrata L. |
| Hits 2132 Download times 2056 Received:January 04, 2015 |
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| DOI
10.11656/j.issn.1673-9043.2014.11 |
| Key Words
Eclipta prostrata L.;chemical constituents;structure identification |
| Author Name | Affiliation | E-mail | | MA Di | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HAN Li-feng | Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China | | | LIU Er-wei | Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China | | | XIA Ming-hui | Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China | | | ZHANG Yi | Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China | | | WANG Tao | Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 300193, China | wangt@263.net |
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| Abstract
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| [Objective] To isolate the chemical constituents of Eclipta prostrata L. and elucidate their structures. [Methods] The compounds were isolated by silica gel, ODS, Sephadex LH-20 column chromatography and PHPLC, and their structures identified by MS and NMR. [Results] Nine compounds were isolated from 70% ethanol extract of Eclipta prostrata L. and identified as 2, 2'; 5', 2''-terthiophene (1), α-formylterthienyl (2), 5-hydroxymethyl-2, 2'; 5', 2''-terthiophene (3), 2,2'; 5',2"-terthiophene-5-carboxylic acid (4), 5'-carboxaldehyde-5-(3-butene-1-ynyl)-2, 2'-bithiophene (5), 4'-chloro-1'-(5-penta-1,3-diyn-1-yl-2-thienyl)-but-2'-yn-3'-ol (6), dihydroactinidiolide (7), loliolide (8) and protocatechoic acid ethyl ester (9), respectively. [Conclusion] Compounds 6-9 are obtained from Eclipta prostrata for the first time. |
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