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| Research progress of the effects of Kallikrein-kinin system on cerebral infarction |
| Hits 1770 Download times 1882 Received:March 01, 2015 |
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| DOI
10.11656/j.issn.1673-9043.2014.15 |
| Key Words
Kallikrein-kinin system;cerebral infarction;biology function |
| Author Name | Affiliation | E-mail | | LI Dan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | DU Yuan-hao | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | jpjs_cn@sina.com | | LI Jing | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| Kallikrein-kinin system exists widely in multiple systems in vivo. It was composed by bradykinin, kininogen, kininogen enzymes and kininase. In recent years, many basic experimental and clinical studies have shown that kallikrein-kinin system were activated after cerebral ischemia. This promoted the improvement of neurological function mainly through the binding of its vasoactive bradykinin and specific receptor, which affected a series of cells and cytokines. Its effects include: reducing infarct size, inhibiting neuronal apoptosis, reducing inflammatory cell infiltration and promoting blood vessel and nerve regeneration. |
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