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| Progress of methods on drug intestinal metabolism |
| Hits 1700 Download times 2175 Received:March 17, 2015 |
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| DOI
10.11656/j.issn.1673-9043.2015.04.15 |
| Key Words
intestinal metabolism;in vitro;in situ;in vivo |
| Author Name | Affiliation | E-mail | | CHEN Li-na | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Ya-nan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | tianyinan2007@163.com | | REN Xiao-liang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | QI Ai-di | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| Intestine not only has many transporters, but also expresses a range of metabolism enzymes, including the enzymes exist in gastrointestinal epithelial cells and digestive tract flora. These enzymes affect the form of the drug in the body and the absorption process and so on. Therefore, intestine first-pass metabolism of drugs is becoming more and more attention and the researching methods are improving. In this paper, the current methods of drug intestinal metabolism and their characteristics were reviewed. |
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